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Multiple curve alignments are needed to derive meaningful representative consensus data of measured time or data series. In combination with a progressive alignment scheme, this enables the computation of multiple curve alignments. These landmarks are used within a heuristic curve registration approach to align profile pairs by mapping similar characteristics onto each other. To this end, characteristic points of the curves' shapes are identified. MICA enables the automatic synchronization of discrete data curves. Mann, Martin Kahle, Hans-Peter Beck, Matthias Bender, Bela Johannes Spiecker, Heinrich Backofen, Rolf MICA: Multiple interval-based curve alignment Conclusions Considering sequence information as well as purely geometric information seems to improve quality of multiple structure alignments, though defining what constitutes the best alignment when sequence and structural measures would suggest different alignments remains a difficult open question. For the SABMark twilight zone benchmark set that captures more remote homology, Formatt and Matt outperform other programs depending on choice of embedded sequence aligner, Formatt produces either better sequence and structural alignments with a smaller core size than Matt, or similarly sized alignments with better sequence similarity, for a small cost in average RMSD. We show that Formatt outperforms Matt and other popular structure alignment programs on the popular HOMSTRAD benchmark. Results We present Formatt, a multiple structure alignment based on the Matt purely geometric multiple structure alignment program, that also takes into account sequence similarity when constructing alignments. These purely geometric methods do not utilize directly protein sequence similarity, and in fact, determining the proper way to incorporate sequence similarity measures into the construction and assessment of protein multiple structure alignments has proved surprisingly difficult. The average pressure limit of the interconnection block was near 5.5 bar and all individual results were well above the 2 bar threshold considered applicable to most microfluidic applicationsįormatt: Correcting protein multiple structural alignments by incorporating sequence alignmentĭirectory of Open Access Journals (Sweden)įull Text Available Abstract Background The quality of multiple protein structure alignments are usually computed and assessed based on geometric functions of the coordinates of the backbone atoms from the protein chains. The interconnection block method is scalable, flexible and supports high interconnection density. Interconnection blocks made from polydimethylsiloxane allow rapid testing of microfluidic chips and unobstructed microfluidic observation. In this paper a method is presented for creating 'interconnection blocks' that are re-usable and provide multiple, aligned and planar microfluidic interconnections. International Nuclear Information System (INIS) Interconnection blocks made from polydimethylsiloxane allow rapid testing of microfluidic chips and unobstructed microfluidic observ. Sabourin, David Snakenborg, Detlef Dufva, Hans Martin Interconnection blocks: a method for providing reusable, rapid, multiple, aligned and planar microfluidic interconnections
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